- Location: Wayne County, Missouri
- Legal status: Village
- Population: 219 (Change since 1990: -13.1%)
- Founded: 1871 by the St. Louis & Iron Mtn. Railroad
- Previously known as: Otter Creek
- Located on MO 49 south of MO 34 and Leeper
- Latitude: 37°03'48" N (+37.0633)
- Longitude: 90°40'54" W (-90.6816)
- Elevation: 431 feet above sea level
- Civil township: Mill Spring
- Land area: 0.21 square miles (134.5 acres)
As the crow flies, Mill Spring is...
Name origin
Named by the railroad company for the large spring here
| Year | Population | Percent change |
|---|
| 1960 | 226 | -- |
| 1970 | 207 | -8.4% |
| 1980 | 257 | +24.2% |
| 1990 | 252 | -1.9% |
| 2000 | 219 | -13.1% |