- Location: Scott County, Missouri
- Legal status: Third-class city
- Population: 16,992 (Change since 1990: -3.7%)
- Founded: April 30, 1860 by John Sikes
- Name origin: John Sikes
- Latitude: 36°52'46" N (+36.8796)
- Longitude: 89°35'07" W (-89.5852)
- Civil township: Richland
- Land area: 17.9 square miles
- Water area: 0.17 square miles (106.4 acres)
As the crow flies, Sikeston is...
Name origin
Named after John Sikes, town founder.
| Year | Population | Percent change |
|---|
| 1880 | 191 | -- |
| 1890 | 636 | +233.0% |
| 1900 | 1,077 | +69.3% |
| 1910 | 3,327 | +208.9% |
| 1920 | 3,613 | +8.6% |
| 1930 | 5,676 | +57.1% |
| 1940 | 7,944 | +40.0% |
| 1950 | 11,640 | +46.5% |
| 1960 | 13,765 | +18.3% |
| 1970 | 14,699 | +6.8% |
| 1980 | 17,431 | +18.6% |
| 1990 | 17,641 | +1.2% |
| 2000 | 16,992 | -3.7% |