- Location: Pemiscot County, Missouri
- Legal status: Third-class city
- Population: 6,760 (Change since 1990: -8.5%)
- Founded: 1857 by John H. Walker and George W. Bushey
- Name origin: Sam Caruthers
- Previously known as: Little Prairie
- Located on the Mississippi River southeast of Hayti near I-155 and MO 84
- Latitude: 36°11'05" N (+36.1847)
- Longitude: 89°39'41" W (-89.6614)
- Elevation: 282 feet above sea level
- Civil township: Little Prairie
- Land area: 5.2 square miles
- Water area: 0.01 square miles (5.7 acres)
As the crow flies, Caruthersville is...
Timeline
- 1794
- Francois Le Sieur established a fort at Little Prairie.
- 1811
- New Madrid earthquakes destroyed Little Prairie.
- 1857
- Caruthersville founded on the site of Little Prairie by John H. Walker and George W. Bushey.
- 1899
- Pemiscot County seat moved from Gayoso to Caruthersville.
| Year | Population | Percent change |
|---|
| 1900 | 2,315 | -- |
| 1910 | 3,655 | +57.9% |
| 1920 | 4,750 | +30.0% |
| 1930 | 4,781 | +0.7% |
| 1940 | 6,612 | +38.3% |
| 1950 | 8,614 | +30.3% |
| 1960 | 8,643 | +0.3% |
| 1970 | 7,350 | -15.0% |
| 1980 | 7,958 | +8.3% |
| 1990 | 7,389 | -7.2% |
| 2000 | 6,760 | -8.5% |