- Population: 19,760 (Change since 1990: -5.6%)
- Created: October 1, 1812
- County seat: New Madrid
- Largest town: New Madrid (Pop. 3,334)
- Name origin: New Madrid
- Arnold (Historical)
- Baderville (Unincorporated)
- Located on US 62 east of Risco
- Latitude & Longitude: 36°33'16" N, 89°44'13" W
- Survey: T. 22 N., R. 12 E., Sec. 14
- Elevation: 286
- Civil township: Como
- School district: New Madrid County R-1
- USGS Quad: Catron
- Barnes Ridge (Historical)
- Baxter (Historical)
- Located somewhere north of Gideon
- Latitude & Longitude: 36°30'39" N, 89°55'54" W
- Survey: T. 22 N., R. 10 E., Sec. 36
- Elevation: 276
- Civil township: Como
- USGS Quad: Malden (Benchmark shown)
- Bayouville (Unincorporated)
- Located on CR 740 north of Route WW
- Latitude & Longitude: 36°39'04" N, 89°21'51" W
- Survey: T. 23 N., R. 16 E., Sec. 7
- Civil township: St. John
- School district: New Madrid County R-1
- USGS Quad: Bayouville
- Map: 1944
- Big Ridge (Unincorporated)
- Located near the intersection of Route A and Route E south of Canalou
- Latitude & Longitude: 36°43'39" N, 89°39'46" W
- Survey: T. 24 N., R. 13 E., Sec. 16
- Elevation: 290
- Civil township: West
- School district: New Madrid County R-1
- USGS Quad: Charter Oak (Not labeled, but does show Big Ridge Church and School)
- Bobtail (Historical)
- Boekerton (Unincorporated)
- Previously known as: Spanish Mill and Weaverville
- Located at the end of Route YY southwest of Portageville
- Latitude & Longitude: 36°24'14" N, 89°45'43" W
- Survey: T. 20 N., R. 12 E., Sec. 4
- Civil township: Portage
- School district: Portageville
- USGS Quad: Boekerton
- Maps: 1866 (Shows Weaverville), 1867 (Weaverville), and 1889 (Weaverville)
- Bowman (Historical)
- Located between Sikeston and Matthews
- Latitude & Longitude: 36°48'25" N, 89°35'23" W
- Elevation: 319
- Civil township: Big Prairie
- USGS Quad: Sikeston South (Benchmark shown)
- Broadwater (Unincorporated)
- Located near the end of Route NN northeast of Malden
- Latitude & Longitude: 36°34'55" N, 89°55'16" W
- Survey: T. 22 N., R. 10 E., Sec. 1
- Civil township: Como
- School district: Risco R-2
- USGS Quad: Malden
- Map: 1918
- Canalou (Fourth-class city)
- Population: 348 (Change since 1990: +9.1%)
- Located at western end of Route H
- Latitude & Longitude: 36°45'16" N, 89°41'13" W
- Catron (Fourth-class city)
- Population: 68 (Change since 1990: -16.0%)
- Located at intersection Route D and Route W
- Latitude & Longitude: 36°36'44" N, 89°42'17" W
- Name origin: Mr. W. C. Catron
- Champion (Historical)
- Located north of Matthews
- Latitude & Longitude: 36°47'17" N, 89°35'16" W
- Survey: T. 25 N., R. 14 E., Sec. 30
- Elevation: 319
- Civil township: Big Prairie
- USGS Quad: Sikeston South (Benchmark shown)
- Como (Unincorporated)
- Located on Route JJ between Parma and Catron
- Latitude & Longitude: 36°37'12" N, 89°45'19" W
- Survey: T. 23 N., R. 12 E., Sec. 22
- Elevation: 285
- Civil township: Como
- School district: New Madrid County R-1
- USGS Quad: Parma
- Conran (Unincorporated)
- Located near the intersection of US 61, Route F, and Route M
- Latitude & Longitude: 36°28'60" N, 89°38'48" W
- Survey: T. 21 N., R. 13 E., Sec. 10
- Elevation: 286
- Civil township: La Font
- School district: Portageville
- USGS Quad: Portageville
- Post office: Dec. 15, 1898 - Nov. 9, 2002
- Delmo (Unincorporated)
- Located on Route E south of Morehouse
- Latitude & Longitude: 36°48'37" N, 89°40'52" W
- Survey: T. 25 N., R. 13 E., Sec. 17
- Civil township: West
- School district: Sikeston R-6
- USGS Quad: Morehouse
- Dillingham Spring (Historical)
- Located north of Tallapoosa
- Latitude & Longitude: 36°31'54" N, 89°49'04" W
- Survey: T. 22 N., R. 11 E., Sec. 24
- Elevation: 274
- Civil township: Como
- USGS Quad: Parma (Benchmark shown)
- Dodds (Unincorporated)
- Alternate name: Spurdod
- Located on Route D between Catron and Lilbourn
- Latitude & Longitude: 36°36'07" N, 89°40'26" W
- Survey: T. 23 N., R. 13 E., Sec. 29
- Civil township: Lewis
- School district: New Madrid County R-1
- USGS Quad: Catron
- Dry Bayou Landing (Historical)
- Located along the Mississippi River just off of Route WW southeast
of Bayouville
- Latitude & Longitude: 36°37'60" N, 89°20'46" W
- Survey: T. 23 N., R. 16 E., Sec. 17
- Elevation: 275
- Civil township: St. John
- USGS Quad: Bayouville (Not shown)
- Dunn (Historical)
- Located at the intersection MO 153 and Route VV south of Gideon
- Latitude & Longitude: 36°24'34" N, 89°56'01" W
- Survey: T. 20 N., R. 10 E., Sec. 1
- Elevation: 267
- Civil township: Anderson
- USGS Quad: Gideon
- Map: MoDOT
- East Lake (Historical)
- Alternate name: Eastlake
- Located northeast of Matthews along Route AA
- Latitude & Longitude: 36°48'25" N, 89°31'13" W
- Survey: T. 25 N., R. 14 E., Sec. 15
- Elevation: 301
- Civil township: Big Prairie
- USGS Quad: Sikeston South (Benchmark shown at Little Vine Church)
- Maps: 1897 Galbraith and 1904 McNally
- Farrenburg (Unincorporated)
- Alternate name: Farrenberg
- Located on CR 707 between La Forge and Henderson Mount
on the old railroad grade
- Latitude & Longitude: 36°41'17" N, 89°30'02" W
- Survey: T. 24 N., R. 14 E., Sec. 25
- Civil township: New Madrid
- School district: New Madrid County R-1
- USGS Quad: Kewanee
- Maps: 1897 Galbraith and 1904 McNally
- Five Point (Historical)
- Located on CR 246 southeast of Malden
- Latitude & Longitude: 36°31'32" N, 89°56'10" W
- Survey: T. 22 N., R. 10 E., Sec. 23
- Elevation: 278
- Civil township: Como
- USGS Quad: Malden (Benchmark shown)
- Point on Gideon and North Island Line between Malden and Baxter
- Forest Spur (Historical)
- Alternate name: Forest
- Located just south of Risco
- Latitude & Longitude: 36°32'23" N, 89°49'04" W
- Elevation: 275
- Civil township: Como
- USGS Quad: Parma (Not shown)
- Frailie (Unincorporated)
- Located near intersections of Route B, Route PP, and CR 375 north
of Wardell
- Latitude & Longitude: 36°25'05" N, 89°49'02" W
- Survey: T. 21 N., R. 11 E., Sec. 36
- Civil township: Portage
- School district: Gideon 37
- USGS Quad: Boekerton
- Garver (Historical)
- Alternate name: New Garver
- Located on Route B south of Frailie
- Latitude & Longitude: 36°24'04" N, 89°49'04" W
- Survey: T. 20 N., R. 11 E., Sec. 1
- Elevation: 269
- Civil township: Portage
- USGS Quad: Boekerton (Benchmark shown)
- Gerkin (Historical)
- Gideon (Fourth-class city)
- Population: 1,113 (Change since 1990: +0.8%)
- Located at intersection MO 153 and MO 162
- Latitude & Longitude: 36°27'17" N, 89°55'07" W
- Name origin: F. E. Gideon
- Founded: ca. 1901
- Post office: Mar. 26, 1902 - Now
- Glendale (Historical)
- Located south of Gideon near the end of Route VV
- Latitude & Longitude: 36°24'38" N, 89°54'20" W
- Survey: T. 21 N., R. 11 E., Sec. 31
- Elevation: 268
- Civil township: Anderson
- USGS Quad: Gideon (Benchmark shown)
- Hartzell (Unincorporated)
- Located on a county road just south of MO 153 between Gideon and Tallapoosa
- Latitude & Longitude: 36°29'07" N, 89°51'21" W
- Survey: T. 21 N., R. 11 E., Sec. 3
- Civil township: Anderson
- School district: Gideon 37
- USGS Quad: Boekerton
- Henderson Mound (Unincorporated)
- Disincorporated sometime after 1960. The population
in 1960 was 41.
- Alternate name: Hough
- Located where the old Cotton Belt railroad alignment
intersects CR 711 between East Prairie and Lilbourn
- Latitude & Longitude: 36°42'42" N, 89°28'07" W
- Survey: T. 24 N., R. 15 E., Sec. 19
- Elevation: 295
- Civil township: Hough
- School district: New Madrid County R-1
- USGS Quad: Henderson Mound
- Station on Cotton Belt Line between Selkirk and Farrenburg
- Higgerson (Historical)
- Howardville (Fourth-class city)
- Population: 342 (Change since 1990: -22.3%)
- Located on US 61/US 62 south of Lilbourn
- Latitude & Longitude: 36°34'03" N, 89°35'56" W
- Hurricane Ridge (Historical)
- Located somewhere southeast of Charter Oak
- Latitude & Longitude: 36°38'03" N, 89°39'51" W
- Elevation: 283
- Civil township: New Madrid
- USGS Quad: Charter Oak (Not shown)
- Hyman (Historical)
- Located west of Parma
- Latitude & Longitude: 36°36'50" N, 89°52'18" W
- Elevation: 282
- Civil township: Como
- USGS Quad: Parma (Not shown)
- Imhoff (Historical)
- Alternate name: Peck
- Located southwest of East Prairie
- Latitude & Longitude: 36°44'17" N, 89°26'13" W
- Survey: T. 24 N., R. 15 E., Sec. 9
- Elevation: 299
- Civil township: Hough
- USGS Quad: Henderson Mound (Benchmark shown at center of Sec. 9)
- Point on Cotton Belt Line between Selkirk and East Prairie
- Jaywye (Unincorporated)
- Located at the intersection of Route F and Route ZZ north of Portageville
- Latitude & Longitude: 36°28'57" N, 89°42'04" W
- Survey: T. 21 N., R. 13 E., Sec. 7
- Elevation: 278
- Civil township: La Font
- School district: Portageville
- USGS Quad: Portageville
- Juanita (Historical)
- Located between Matthews and Sikeston
- Latitude & Longitude: 36°49'13" N, 89°35'28" W
- Survey: T. 25 N., R. 14 E., Sec. 7
- Elevation: 322
- Civil township: Big Prairie
- USGS Quad: Sikeston South (Benchmark shown)
- Kewanee (Unincorporated)
- Located on Route W west of US 61
- Latitude & Longitude: 36°40'16" N, 89°34'26" W
- Survey: T. 23 N., R. 14 E., Sec. 5
- Elevation: 302
- Civil township: New Madrid
- School district: New Madrid County R-1
- USGS Quad: Kewanee
- Krepin (Historical)
- Located about a mile northwest of Catron
- Latitude & Longitude: 36°37'07" N, 89°43'13" W
- Elevation: 280
- Civil township: Como
- USGS Quad: Catron (Not shown)
- Point on the Cotton Belt Line between Como and Catron
- La Font (Historical)
- La Forge (Unincorporated)
- Alternate name: Laforge
- Located on Route P east of I-55 Exit 52
- Latitude & Longitude: 36°40'17" N, 89°31'32" W
- Survey: T. 23 N., R. 14 E., Sec. 3
- Civil township: New Madrid
- School district: New Madrid County R-1
- USGS Quad: Kewanee
- Station on Cotton Belt Line between Ristine and Farrenburg
- Named for the LaForge family, possibly
Emma C. LaForge in particular, who was the second
wife of Lilbourn A. Lewis, founder of Lilbourn.
- Lilbourn (Fourth-class city)
- Population: 1,303 (Change since 1990: -5.4%)
- Located near intersection Route D and Route U west of New Madrid
- Latitude & Longitude: 36°35'27" N, 89°36'46" W
- Name origin: Lilbourn Anexeamander Lewis
- Founded: October 7, 1903 by Lilbourn A. Lewis
- Linda (Unincorporated)
- Located on county road near the intersection of MO 162 and Route M
- Latitude & Longitude: 36°24'39" N, 89°32'49" W
- Survey: T. 21 N., R. 14 E., Sec. 33
- Elevation: 303
- Civil township: Le Sieur
- School district: Portageville
- USGS Quad: Point Pleasant
- Little River (Historical)
- Located southwest of Sikeston
- Latitude & Longitude: 36°51'16" N, 89°39'48" W
- Survey: T. 26 N., R. 13 E., Sec. 33
- Elevation: 302
- Civil township: West
- USGS Quad: Morehouse (Not shown)
- Station on the C.A.T. Line between Morehouse and Browns
- Maps: 1872 Colton and 1881 Chester RR
- Lone Star (Unincorporated)
- Located on CR 335 near the end of Route EE west of Marston and south of Baderville
- Latitude & Longitude: 36°30'55" N, 89°26'28" W
- Survey: T. 22 N., R. 12 E., Sec. 26
- Civil township: St. John
- School district: New Madrid County R-1
- USGS Quad: Catron
- Lorwood (Unincorporated)
- Located near the intersection of Route D and CR 540 west of Parma
- Latitude & Longitude: 36°36'34" N, 89°51'21" W
- Survey: T. 23 N., R. 11 E., Sec. 27
- Civil township: Como
- School district: New Madrid County R-1
- USGS Quad: Parma
- Map: MoDOT
- Marston (Fourth-class city)
- Population: 610 (Change since 1990: -11.7%)
- Located at intersection US 61 and Route EE just west of I-55 interchange
- Latitude & Longitude: 36°31'01" N, 89°36'37" W
- Post office: Nov. 17, 1898 - Now
- Matthews (Fourth-class city)
- Population: 605 (Change since 1990: -1.5%)
- Located on Route H between US 61 and Route AE
- Latitude & Longitude: 36°45'28" N, 89°35'12" W
- Medal (Historical)
- Located northeast of Charter Oak, possibly along Route A
- Latitude & Longitude: 36°43'44" N, 89°41'57" W
- Survey: T. 24 N., R. 13 E., Sec. 18
- Elevation: 287
- Civil township: West
- USGS Quad: Charter Oak (Not shown)
- Melby (Historical)
- Located west of Parma along the railroad grade
- Latitude & Longitude: 36°36'19" N, 89°52'43" W
- Survey: T. 23 N., R. 11 E., Sec. 28
- Elevation: 280
- Civil township: Como
- USGS Quad: Malden (Not shown)
- Mitchell (Historical)
- Morehouse (Fourth-class city)
- Population: 1,015 (Change since 1990: -5.0%)
- Located at intersection MO 114 and Route Z just north of US 61
in the far northwest corner of New Madrid County
- Latitude & Longitude: 36°50'44" N, 89°41'28" W
- Name origin: Albert Pickett Morehouse
- Founded: ca. 1888
- New Madrid (Fourth-class city)
- Population: 3,334 (Change since 1990: -0.5%)
- Latitude & Longitude: 36°35'16" N, 89°32'09" W
- Name origin: Madrid, Spain
- Founded: 1783 by Francois and Joseph LaSieur
- Nordlow (Historical)
- Located between Malden and Parma along the railroad
- Latitude & Longitude: 36°35'49" N, 89°53'43" W
- Elevation: 280
- Civil township: Como
- USGS Quad: Malden (Not shown)
- North Lilbourn (Village)
- Population: 95 (Change since 1990: -39.5%)
- Located adjacent to Lilbourn
- Latitude & Longitude: 36°36'02" N, 89°37'15" W
- Noxall (Unincorporated)
- Located on Route HH between US 61 and Route AE south of Matthews
- Latitude & Longitude: 36°43'21" N, 89°34'40" W
- Survey: T. 24 N., R. 14 E., Sec. 18
- Civil township: Big Prairie
- School district: New Madrid County R-1
- USGS Quad: Kewanee
- Ogden (Historical)
- Located south of Sikeston
- Latitude & Longitude: 36°44'40" N, 89°33'23" W
- Elevation: 307
- Civil township: Big Prairie
- USGS Quad: Kewanee (Not shown)
- Maps: 1847 (Shows "Ogden P.O."), 1857 Johnson, 1866, 1867, and 1886
- Otis (Historical)
- Located north of Lilbourn
- Latitude & Longitude: 36°36'48" N, 89°36'12" W
- Survey: T. 23 N., R. 13 E., Sec. 25
- Elevation: 284
- Civil township: Lewis
- USGS Quad: New Madrid (Not shown)
- Otto Spur (Historical)
- Located northeast of Charter Oak along the old railroad grade
- Latitude & Longitude: 36°43'57" N, 89°41'58" W
- Survey: T. 24 N., R. 13 E., Sec. 7
- Elevation: 283
- Civil township: West
- USGS Quad: Charter Oak (Not shown)
- Parma (Fourth-class city)
- Population: 852 (Change since 1990: -14.4%)
- Located at intersection MO 153 and Route D
- Latitude & Longitude: 36°36'48" N, 89°49'03" W
- Founded: 1900
- Pioneer (Historical)
- Located just southwest of Henderson Mound along the old railroad grade
- Latitude & Longitude: 36°42'12" N, 89°28'48" W
- Survey: T. 24 N., R. 15 E., Sec. 19
- Elevation: 299
- Civil township: Hough
- USGS Quad: Henderson Mound (Benchmark shown)
- Point Pleasant (Unincorporated)
- Located on Route M east of Route KK intersection
- Latitude & Longitude: 36°27'09" N, 89°34'28" W
- Elevation: 290
- Civil township: Le Sieur
- School district: Portageville
- USGS Quad: Point Pleasant
- Map: MoDOT (Shows incorporation)
- Portageville (Fourth-class city)
- Population: 3,295 (Change since 1990: -3.1%)
- Located near intersections of I-55, US 61, and MO 162
- Latitude & Longitude: 36°25'47" N, 89°42'04" W
- Name origin: Portage Bay
- Founded: 1872
- Riddles Point (Historical)
- Located on the Mississippi River southeast of Point Pleasant near the end of MO 162
- Latitude & Longitude: 36°22'49" N, 89°31'16" W
- Survey: T. 20 N., R. 14 E., Sec. 15
- Civil township: Le Sieur
- USGS Quad: Point Pleasant
- Maps: 1857 Johnson (Shown in Pemiscot County), 1862 New Madrid (Shown opposite Tiptonville), 1872, and 1880 (Shown as Ruddles Point)
- Risco (Fourth-class city)
- Population: 392 (Change since 1990: -9.7%)
- Located just west of US 62 and MO 153 intersection
- Latitude & Longitude: 36°33'06" N, 89°49'12" W
- Ristine (Unincorporated)
- Alternate name: Ristin
- Located on US 61 north of New Madrid
- Latitude & Longitude: 36°38'56" N, 89°32'53" W
- Survey: T. 23 N., R. 14 E., Sec. 9
- Civil township: New Madrid
- School district: New Madrid County R-1
- USGS Quad: Kewanee
- Map: 1897 McNally (Ristine Sta. or Ristin P.O.)
- Rudd (Historical)
- Sarff (Historical)
- Located somewhere north of Gideon
- Latitude & Longitude: 36°29'22" N, 89°55'20" W
- Survey: T. 21 N., R. 10 E., Sec. 1
- Elevation: 270
- Civil township: Anderson
- USGS Quad: Gideon (Not shown)
- Selkirk (Historical)
- Located northeast of Henderson Mound
- Latitude & Longitude: 36°43'26" N, 89°27'17" W
- Survey: T. 24 N., R. 15 E., Sec. 17
- Elevation: 299
- Civil township: Hough
- USGS Quad: Henderson Mound (Benchmark shown at center of Sec. 17)
- Point on Cotton Belt Line between Henderson Mound and Imhoff
- Sky (Historical)
- Located northwest of Lilbourn, probably near the Route D crossing of Little River
- Latitude & Longitude: 36°36'02" N, 89°38'32" W
- Survey: T. 23 N., R. 13 E., Sec. 27
- Elevation: 285
- Civil township: Lewis
- USGS Quad: Catron (Benchmark shown)
- Small (Historical)
- Tallapoosa (Village)
- Population: 204 (Change since 1990: +17.2%)
- Located just north of MO 153 and Route B intersection
- Latitude & Longitude: 36°30'27" N, 89°49'08" W
- Tram Switch (Historical)
- Located south of Morehouse, just west of Route E
- Latitude & Longitude: 36°47'36" N, 89°41'21" W
- Survey: T. 25 N., R. 13 E., Sec. 19
- Elevation: 292
- Civil township: West
- USGS Quad: Morehouse (Benchmark shown)
- Point on Frisco railroad between Canalou and Morehouse
- Maps: 1904 McNally and 1928 Frisco
- Turner (Historical)
- Located northeast of Malden
- Latitude & Longitude: 36°35'16" N, 89°54'45" W
- Survey: T. 23 N., R. 11 E., Sec. 31
- Elevation: 279
- Civil township: Como
- USGS Quad: Malden (Not shown)
- Point on Cotton Belt line between Nordlaw and Broadwater
- Warrington (Historical)
- Wila (Historical)
- Located between Como and Parma
- Latitude & Longitude: 36°36'60" N, 89°46'60" W
- Survey: T. 23 N., R. 12 E., Sec. 20
- Elevation: 281
- Civil township: Como
- USGS Quad: Parma (Not shown)
- Williams Landing (Historical)
- Winchester (Historical)
- Winchester was a temporary New Madrid county seat
from about 1816 to 1822, but then quickly declined.
- Located about a half-mile south of downtown Sikeston
along US 61, which probably puts it within the modern-day
city limits of Sikeston
- Named for Henderson Winchester, who lived nearby
- Maps: 1830 Tanner, 1835 (Shows Winchester in Stoddard County), 1857 Colton, 1865 (Shows both Sikestown and Winchester), and 1872
- Sources: Goodspeed (p. 463), Beck 1823 (Described as county seat, and p. 242)
| Year | Population | Percent change |
|---|
| 1820 | 2,445 | -- |
| 1830 | 2,350 | -3.9% |
| 1840 | 4,554 | +93.8% |
| 1850 | 5,541 | +21.7% |
| 1860 | 5,654 | +2.0% |
| 1870 | 6,357 | +12.4% |
| 1880 | 7,694 | +21.0% |
| 1890 | 9,317 | +21.1% |
| 1900 | 11,280 | +21.1% |
| 1910 | 19,488 | +72.8% |
| 1920 | 25,180 | +29.2% |
| 1930 | 30,262 | +20.2% |
| 1940 | 39,787 | +31.5% |
| 1950 | 39,444 | -0.9% |
| 1960 | 31,350 | -20.5% |
| 1970 | 32,981 | +5.2% |
| 1980 | 22,945 | -30.4% |
| 1990 | 20,928 | -8.8% |
| 2000 | 19,760 | -5.6% |