- Location: Jefferson County, Missouri
- Legal status: City
- Population: 6,375 (Change since 1990: +6.4%)
- Name origin: Hernando De Soto
- Located along MO 21 south of Hillsboro
- Latitude: 38°08'22" N (+38.1394)
- Longitude: 90°33'18" W (-90.5550)
- Elevation: 503 feet above sea level
- Civil township: Valle
- Land area: 3.8 square miles
As the crow flies, De Soto is...
| Year | Population | Percent change |
|---|
| 1900 | 5,611 | -- |
| 1910 | 4,721 | -15.9% |
| 1920 | 5,003 | +6.0% |
| 1930 | 5,069 | +1.3% |
| 1940 | 5,121 | +1.0% |
| 1950 | 5,357 | +4.6% |
| 1960 | 5,804 | +8.3% |
| 1970 | 5,984 | +3.1% |
| 1980 | 5,993 | +0.2% |
| 1990 | 5,993 | None |
| 2000 | 6,375 | +6.4% |