- Population: 9,590 (Change since 1990: -9.7%)
- Created: March 4, 1819
- County seat: Cairo
- Largest town: Cairo (Pop. 3,632)
- Name origin: William M. Alexander
- Cache (Unincorporated)
- Previously known as: Beech Ridge
- Located along IL 3 between Unity and Cairo
- Latitude & Longitude: 37°06'00" N, 89°15'41" W
- Survey: T. 16 S., R. 1 W., Sec. 19
- Elevation: 326
- Precinct: Miller
- USGS Quad: Cache
- Post office: Apr. 3, 1897 - Oct. 15, 1914 (Beech Ridge); Oct. 15, 1914 - Oct. 5, 2002 (Cache)
- Maps: 1895 McNally (Beech Ridge) and 1898 (Beech Ridge)
- Cairo (City)
- Population: 3,632 (Change since 1990: -25.1%)
- Located at the southernmost tip of Illinois near the intersections
of I-57, US 51, US 60, US 62, and IL 3
- Latitude & Longitude: 37°00'19" N, 89°10'35" W
- Post office: Nov. 8, 1837 - Now
- Cairo Junction (Unincorporated)
- Located just northwest of Future City
- Latitude & Longitude: 37°02'27" N, 89°11'30" W
- Survey: T. 17 S., R. 1 W., Sec. 14
- Elevation: 310
- Precinct: Cairo
- USGS Quad: Cairo
- Clank (Unincorporated)
- Located northeast of Olive Branch
- Latitude & Longitude: 37°11'18" N, 89°19'30" W
- Survey: T. 15 S., R. 2 W., Sec. 27
- Elevation: 343
- Precinct: Olive Branch
- USGS Quad: Tamms
- Davey Switch (Unincorporated)
- Located northeast of Clank
- Latitude & Longitude: 37°12'07" N, 89°18'28" W
- Survey: T. 15 S., R. 2 W., Sec. 23
- Precinct: Sandusky
- USGS Quad: Tamms
- Dawleys (Unincorporated)
- Located northwest of Sandusky
- Latitude & Longitude: 37°12'45" N, 89°17'46" W
- Survey: T. 15 S., R. 2 W., Sec. 14
- Elevation: 345
- Precinct: Sandusky
- USGS Quad: Tamms
- Delta (Historical)
- Probably located along Delta Road, perhaps near Grapevine Trail
(Co. Hwy. 4)
- Diswood (Unincorporated)
- Located west of Tamms
- Latitude & Longitude: 37°13'53" N, 89°19'22" W
- Survey: T. 15 S., R. 2 W., Sec. 10
- Elevation: 360
- Precinct: Sandusky
- USGS Quad: Tamms
- Map: 1897 Galbraith
- East Cape Girardeau (Village)
- Population: 437 (Change since 1990: -3.1%)
- Located on IL 146 across the bridge from Cape Girardeau, MO
- Latitude & Longitude: 37°17'45" N, 89°29'46" W
- Elco (Unincorporated)
- Previously known as: Toledo and Hazlewood
- Latitude & Longitude: 37°18'02" N, 89°15'57" W
- Survey: T. 14 S., R. 1 W., Sec. 18
- Elevation: 375
- Precinct: Elco
- USGS Quad: Mill Creek
- Map: 1876 atlas (Toledo P.O. or Elco Sta.)
- Fayville (Unincorporated)
- Previously known as: Santa Fe
- Located along Fayville Road south of Thebes and opposite
the Mississippi River from Commerce
- Latitude & Longitude: 37°09'53" N, 89°25'36" W
- Survey: T. 15 S., R. 3 W.
- Elevation: 360
- Precinct: Thebes
- USGS Quad: Thebes
- Maps: 1854 (Santa Fe), 1876 atlas (Santa Fe), and 1897 Galbraith (Santa Fe)
- Future City (Unincorporated)
- Located along US 51 just north of Cairo
- Latitude & Longitude: 37°01'44" N, 89°11'17" W
- Survey: T. 17 S., R. 1 W., Sec. 14
- Elevation: 310
- Precinct: Cairo
- USGS Quad: Cairo
- Gale (Unincorporated)
- Located near the intersection IL 3 and Old IL 3
north of Thebes
- Latitude & Longitude: 37°14'56" N, 89°26'51" W
- Survey: T. 14 S., R. 3 W., Sec. 33
- Elevation: 350
- Precinct: East Cape
- USGS Quad: Thebes
- Golden Lily (Unincorporated)
- Located along Old US 51 north of Urbandale
- Latitude & Longitude: 37°04'32" N, 89°11'09" W
- Survey: T. 17 S., R. 1 W., Sec. 35
- Elevation: 315
- USGS Quad: Cairo
- Klondike (Unincorporated)
- Located along IL 3 northwest of Cairo, near the airport
- Latitude & Longitude: 37°03'46" N, 89°13'54" W
- Survey: T. 17 S., R. 1 W., Sec. 4-5
- Elevation: 313
- USGS Quad: Cairo
- McClure (Unincorporated)
- Previously known as: Clear Creek Landing
- Located at intersection IL 3 and Grapevine Trail Road, northeast
of East Cape Girardeau
- Latitude & Longitude: 37°19'04" N, 89°25'53" W
- Survey: T. 14 S., R. 3 W.
- Elevation: 343
- Precinct: McClure
- USGS Quad: McClure
- Map: 1876 atlas (Clear Creek Landing)
- Miller City (Unincorporated)
- Located south of Olive Branch near the intersection
of Miller City Road (Co. Hwy. 2) and Promised Land Road.
- Latitude & Longitude: 37°06'39" N, 89°21'22" W
- Survey: T. 16 S., R. 2 W., Sec. 20
- Elevation: 333
- Precinct: Miller
- USGS Quad: Cache
- Post office: Jan. 11, 1890 - Oct. 27, 1911 (Willard); Oct. 27, 1911 - Now
- North Junction (Historical)
- Located on the railroad between Thebes and Gale just south
of the crossing over Miller Creek
- Latitude & Longitude: 37°14'19" N, 89°26'43" W
- Survey: T. 15 S., R. 3 W., Sec. 4
- Precinct: Thebes
- USGS Quad: Thebes (Not shown)
- Olive Branch (Unincorporated)
- Located along IL 3 southeast of Thebes near Horseshow Lake
- Latitude & Longitude: 37°10'07" N, 89°21'06" W
- Survey: T. 15 S., R. 2 W., Sec. 32
- Elevation: 340
- Precinct: Olive Branch
- USGS Quad: Tamms
- Post office: May 12, 1876 - Now
- Roth (Unincorporated)
- Located west of Cache along Miller City Road (Co. Hwy. 2)
- Latitude & Longitude: 37°06'01" N, 89°18'26" W
- Survey: T. 16 S., R. 2 W., Sec. 23
- Elevation: 326
- Precinct: Miller
- USGS Quad: Cache
- Sandusky (Unincorporated)
- Previously known as: Helena
- Located between Tamms and Unity along IL 127
- Latitude & Longitude: 37°12'09" N, 89°16'20" W
- Survey: T. 15 S., R. 2 W., Sec. 13, 24
- Elevation: 340
- Precinct: Sandusky
- USGS Quad: Tamms
- Map: 1876 atlas (Helena)
- Shasta (Historical)
- Located near Tankville
- Latitude & Longitude: 37°07'54" N, 89°23'42" W
- Elevation: 333
- Precinct: Olive Branch
- USGS Quad: Thebes (Benchmark shown)
- South Junction (Historical)
- Located along the railroad just northeast of Thebes, south of
North Junction
- Latitude & Longitude: 37°13'42" N, 89°26'54" W
- Survey: T. 15 S., R. 3 W., Sec. 9
- Precinct: Thebes
- USGS Quad: Thebes (Not shown)
- Tamms (Village)
- Population: 724 (Change since 1990: -3.2%)
- Located along IL 127
- Latitude & Longitude: 37°14'06" N, 89°16'12" W
- Tankville (Unincorporated)
- Located northwest of Miller City near the Mississippi River
- Latitude & Longitude: 37°07'37" N, 89°23'01" W
- Survey: T. 16 S., R. 3 W., Sec. 13
- Elevation: 330
- Precinct: Olive Branch
- USGS Quad: Thebes
- Tatumville (Unincorporated)
- Located northwest of Tamms
- Latitude & Longitude: 37°15'28" N, 89°16'46" W
- Survey: T. 14 S., R. 2 W., Sec. 36
- Elevation: 390
- Precinct: Tamms
- USGS Quad: Mill Creek
- Thebes (Village)
- Population: 478 (Change since 1990: +3.7%)
- Located just off IL 3 along the Mississippi River opposite
Scott City
- Latitude & Longitude: 37°13'15" N, 89°27'39" W
- Post office: Dec. 13, 1845 - Now
- Unity (Unincorporated)
- Alternate name: Hodges Park
- Located along IL 127 south of Sandusky
- Latitude & Longitude: 37°08'59" N, 89°16'22" W
- Survey: T. 16 S., R. 2 W., Sec. 1
- Elevation: 330
- Precinct: Sandusky
- USGS Quad: Tamms (Labeled Unity or Hodges Park Sta.)
- Maps: 1854, 1876 atlas, 1892 McNally (Hodges Park), and 1895 McNally (Hodges Park)
- Urbandale (Unincorporated)
- Located along Old US 51 between Future City and Golden Lily
- Latitude & Longitude: 37°03'10" N, 89°11'09" W
- Survey: T. 17 S., R. 1 W., Sec.
- Elevation: 311
- USGS Quad: Cairo
- Willard (Unincorporated)
- Located south of Miller City
- Latitude & Longitude: 37°05'11" N, 89°21'08" W
- Survey: T. 16 S., R. 2 W., Sec. 32
- Elevation: 326
- Precinct: Miller
- USGS Quad: Cache
- Map: 1897 Galbraith
Name origin
Named for William M. Alexander, an early settler and later a
state senator
| Year | Population | Percent change |
|---|
| 1820 | 626 | -- |
| 1830 | 1,390 | +122.0% |
| 1840 | 3,313 | +138.3% |
| 1850 | 2,484 | -25.0% |
| 1860 | 4,698 | +89.1% |
| 1870 | 10,564 | +124.9% |
| 1880 | 14,808 | +40.2% |
| 1890 | 16,563 | +11.9% |
| 1900 | 19,384 | +17.0% |
| 1910 | 22,741 | +17.3% |
| 1920 | 23,980 | +5.4% |
| 1930 | 22,542 | -6.0% |
| 1940 | 25,496 | +13.1% |
| 1950 | 20,316 | -20.3% |
| 1960 | 16,061 | -20.9% |
| 1970 | 12,015 | -25.2% |
| 1980 | 12,264 | +2.1% |
| 1990 | 10,626 | -13.4% |
| 2000 | 9,590 | -9.7% |