- Population: 12,419,293 (Change since 1990: +8.6%)
- Statehood: Dec. 3, 1818
- Capital city: Springfield
- Highest point: Charles Mound, 1235 ft.
- Lowest point: Fort Defiance, 279 ft.
- Alexander County
- Population: 9,590 (Change since 1990: -9.7%)
- Created: March 4, 1819
- County seat: Cairo
- Largest town: Cairo (Pop. 3,632)
- Name origin: William M. Alexander
- Gallatin County
- Population: 6,445 (Change since 1990: -6.7%)
- Created: September 14, 1812
- County seat: Shawneetown
- Largest town: Shawneetown (Pop. 1,410)
- Name origin: Albert Gallatin
- Hardin County
- Population: 4,800 (Change since 1990: -7.5%)
- Created: March 2, 1839
- County seat: Elizabethtown
- Largest town: Rosiclare (Pop. 1,213)
- Name origin: Hardin County, Kentucky
- Jackson County
- Population: 61,296 (Change since 1990: +0.4%)
- Created: January 10, 1816
- County seat: Murphysboro
- Largest town: Carbondale (Pop. 20,681)
- Name origin: Andrew Jackson
- Johnson County
- Population: 12,878 (Change since 1990: +13.5%)
- Created: September 14, 1812
- County seat: Vienna
- Largest town: Vienna (Pop. 1,234)
- Name origin: Richard M. Johnson
- Massac County
- Population: 15,161 (Change since 1990: +2.8%)
- Created: March 3, 1843
- County seat: Metropolis
- Largest town: Metropolis (Pop. 6,482)
- Name origin: Fort Massac
- Pope County
- Population: 4,413 (Change since 1990: +0.9%)
- Created: January 10, 1816
- County seat: Golconda
- Largest town: Golconda (Pop. 726)
- Name origin: Nathaniel Pope
- Pulaski County
- Population: 7,348 (Change since 1990: -2.3%)
- Created: March 3, 1843
- County seat: Mound City
- Largest town: Mounds (Pop. 1,117)
- Name origin: Casimir Pulaski
- Randolph County
- Population: 33,839 (Change since 1990: -2.2%)
- Created: October 5, 1795
- County seat: Chester
- Largest town: Chester (Pop. 5,185)
- Name origin: Edmund Randolph
- Saline County
- Population: 26,733 (Change since 1990: +0.7%)
- Created: February 25, 1847
- County seat: Harrisburg
- Largest town: Harrisburg (Pop. 9,860)
- Name origin: Saline Creek
- Union County
- Population: 18,293 (Change since 1990: +3.8%)
- Created: January 2, 1818
- County seat: Jonesboro
- Largest town: Anna (Pop. 5,136)
- Name origin: Federal union
- Williamson County
- Population: 61,296 (Change since 1990: +6.2%)
- Created: February 28, 1839
- County seat: Marion
- Largest town: Marion (Pop. 16,035)
- Name origin: Williamson County, Tennessee
| Year | Population | Percent change |
|---|
| 1820 | 55,211 | -- |
| 1830 | 157,445 | +185.2% |
| 1840 | 476,183 | +202.4% |
| 1850 | 851,470 | +78.8% |
| 1860 | 1,711,033 | +101.0% |
| 1870 | 2,539,891 | +48.4% |
| 1880 | 3,077,871 | +21.2% |
| 1890 | 3,826,351 | +24.3% |
| 1900 | 4,821,550 | +26.0% |
| 1910 | 5,638,591 | +16.9% |
| 1920 | 6,485,280 | +15.0% |
| 1930 | 7,630,654 | +17.7% |
| 1940 | 7,897,241 | +3.5% |
| 1950 | 8,712,176 | +10.3% |
| 1960 | 10,081,158 | +15.7% |
| 1970 | 11,113,976 | +10.2% |
| 1980 | 11,427,414 | +2.8% |
| 1990 | 11,430,602 | +0.0% |
| 2000 | 12,419,293 | +8.6% |